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recombinant human glial growth factor 2 (ggf2; neuregulin-1beta3; usan - cimaglermin alfa)  (Acorda Inc)

 
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    Acorda Inc recombinant human glial growth factor 2 (ggf2; neuregulin-1beta3; usan - cimaglermin alfa)
    Recombinant Human Glial Growth Factor 2 (Ggf2; Neuregulin 1beta3; Usan Cimaglermin Alfa), supplied by Acorda Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/recombinant+human+ggf2/ggf+2/pmc05926239-71-2-16
    Average 90 stars, based on 1 article reviews
    recombinant human glial growth factor 2 (ggf2; neuregulin-1beta3; usan - cimaglermin alfa) - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    Mouse Assay:

    Article Title: NG2 cell response in the CNP-EGFP mouse after contusive spinal cord injury
    Article Snippet: .. Mice (N = 3) were injected with 0.8mg/kg recombinant human GGF2 (Acorda Pharmaceutical, Hawthorne NY) and 0.02mg/kg FGF2 (Peprotech, Rocky Hill NJ) in 500μl of sterile 0.9% saline once daily, subcutaneously, for 8 days following injury, beginning 1 day post injury. ..

    Injection:

    Article Title: NG2 cell response in the CNP-EGFP mouse after contusive spinal cord injury
    Article Snippet: .. Mice (N = 3) were injected with 0.8mg/kg recombinant human GGF2 (Acorda Pharmaceutical, Hawthorne NY) and 0.02mg/kg FGF2 (Peprotech, Rocky Hill NJ) in 500μl of sterile 0.9% saline once daily, subcutaneously, for 8 days following injury, beginning 1 day post injury. ..

    Recombinant:

    Article Title: NG2 cell response in the CNP-EGFP mouse after contusive spinal cord injury
    Article Snippet: .. Mice (N = 3) were injected with 0.8mg/kg recombinant human GGF2 (Acorda Pharmaceutical, Hawthorne NY) and 0.02mg/kg FGF2 (Peprotech, Rocky Hill NJ) in 500μl of sterile 0.9% saline once daily, subcutaneously, for 8 days following injury, beginning 1 day post injury. ..

    Article Title: GGF2 is neuroprotective in a rat model of cavernous nerve injury-induced erectile dysfunction
    Article Snippet: .. Recombinant human GGF2 and vehicle were provided by Acorda Therapeutics, Inc. (Ardsley, NY, USA). ..

    Article Title: GGF2 (Nrg1-β3) treatment enhances NG2+ cell response and improves functional recovery after spinal cord injury.
    Article Snippet: The adult spinal cord contains a pool of endogenous glial precursor cells, which spontaneously respond to spinal cord injury (SCI) with increased proliferation.. These include oligodendrocyte precursor cells that express the NG2 proteoglycan and can differentiate into mature oligodendrocytes.. Thus, a potential approach for SCI treatment is to enhance the proliferation and differentiation of these cells to yield more functional mature glia and improve remyelination of surviving axons.

    Sterility:

    Article Title: NG2 cell response in the CNP-EGFP mouse after contusive spinal cord injury
    Article Snippet: .. Mice (N = 3) were injected with 0.8mg/kg recombinant human GGF2 (Acorda Pharmaceutical, Hawthorne NY) and 0.02mg/kg FGF2 (Peprotech, Rocky Hill NJ) in 500μl of sterile 0.9% saline once daily, subcutaneously, for 8 days following injury, beginning 1 day post injury. ..

    Saline:

    Article Title: NG2 cell response in the CNP-EGFP mouse after contusive spinal cord injury
    Article Snippet: .. Mice (N = 3) were injected with 0.8mg/kg recombinant human GGF2 (Acorda Pharmaceutical, Hawthorne NY) and 0.02mg/kg FGF2 (Peprotech, Rocky Hill NJ) in 500μl of sterile 0.9% saline once daily, subcutaneously, for 8 days following injury, beginning 1 day post injury. ..



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    Effects of exogenous growth factors on sphere formation from purified NG2+ cells. Data are shown from a representative preparation of cells from tissue at 3 days after SCI and uninjured spinal cord. A: The total sphere number after 7 days in vitro is increased by the addition of FGF2 to the defined media. The combination of FGF2 and <t>GGF2</t> further increases sphere production from NG2+ cells isolated from the injured spinal cord. Data represent mean ± SEM for n = 4 culture wells in each group. B: After 2 weeks in culture, the spheres in each culture well are harvested, dissociated with trypsin and counted by hemocytometer to estimate the total numbers of cells per well which increased with medium containing FGF2 and GGF2. Data represent mean ± SEM for n = 4 culture wells in each group. *Significantly different from uninjured controls (A) or medium without growth factors (B); #significantly different from any other condition.
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    Image Search Results


    Effects of exogenous growth factors on sphere formation from purified NG2+ cells. Data are shown from a representative preparation of cells from tissue at 3 days after SCI and uninjured spinal cord. A: The total sphere number after 7 days in vitro is increased by the addition of FGF2 to the defined media. The combination of FGF2 and GGF2 further increases sphere production from NG2+ cells isolated from the injured spinal cord. Data represent mean ± SEM for n = 4 culture wells in each group. B: After 2 weeks in culture, the spheres in each culture well are harvested, dissociated with trypsin and counted by hemocytometer to estimate the total numbers of cells per well which increased with medium containing FGF2 and GGF2. Data represent mean ± SEM for n = 4 culture wells in each group. *Significantly different from uninjured controls (A) or medium without growth factors (B); #significantly different from any other condition.

    Journal:

    Article Title: Interaction of NG2 + glial progenitors and microglia/macrophages from the injured spinal cord

    doi: 10.1002/glia.20932

    Figure Lengend Snippet: Effects of exogenous growth factors on sphere formation from purified NG2+ cells. Data are shown from a representative preparation of cells from tissue at 3 days after SCI and uninjured spinal cord. A: The total sphere number after 7 days in vitro is increased by the addition of FGF2 to the defined media. The combination of FGF2 and GGF2 further increases sphere production from NG2+ cells isolated from the injured spinal cord. Data represent mean ± SEM for n = 4 culture wells in each group. B: After 2 weeks in culture, the spheres in each culture well are harvested, dissociated with trypsin and counted by hemocytometer to estimate the total numbers of cells per well which increased with medium containing FGF2 and GGF2. Data represent mean ± SEM for n = 4 culture wells in each group. *Significantly different from uninjured controls (A) or medium without growth factors (B); #significantly different from any other condition.

    Article Snippet: We thank Acorda Therapeutics for the gift of the human recombinant GGF2.

    Techniques: Purification, In Vitro, Isolation